Abstract
Summary
The ability of human breast tumor preparations to hydrolyze DHEA, estrone, and testosterone sulfates was studied. Of the 85 tumor preparations examined, 31 tumors contained an estrogen sulfatase activity and 19 of which also exhibited sulfatase activity toward DHEA; but there was no testosterone sulfatase in any of the 31 tumor preparations. The remaining 54 tumor preparations showed no sulfatase activity toward any of the three steroid sulfates examined. The present data also disclose that the levels of sulfatase activities do not affect those of sulfotransferase activities in the tumor preparations. Further, the ratio of sulfotransferase activity with DHEA and estradiol as substrates is not related to the sulfatase activity in these tumor preparations.
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