Abstract
Summary
Erythrocyte membrane proteins from normal subjects and four patients with sickle cell anemia were studied. The proteins were solubilized with SDS and 2-mercapto-ethanol and separated on a discontinuous disc polyacrylamide gel system. No variations in major protein groups were found between normal and hemoglobin SS-containing erythrocytes. ISC formed in vitro were also studied and showed no deviation from the normal pattern. The significance of these studies has been discussed.
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