Abstract
Summary
We used the recently described rat popliteal node assay, a sensitive in vivo test of thymic-dependent lymphocyte funciton, to measure the effects of cis-platinum (II) diamminedichloride and gallium nitrate on the ability of spleen cells from treated parental rats to induce a graft-versus-host reaction in hybrid recipients. In doses sufficient to cause morbidity and weight loss of the donor rats, no significant suppression of the reaction could be demonstrated.
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