Abstract
Summary
In prepubertal rats injected with PMSG an ovulatory surge of LH was secreted between the hours of 1400 and 1800 on the second day after PMSG. Administration of phenobarbital at 1100 prevented the LH surge and ovulation from occurring; however, if progesterone was injected 1 hr prior to the phenobarbital, most rats ovulated. No consistent evidence of an LH surge was seen in rats treated with progesterone and phenobarbital even though they ovulated.
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