Abstract
Summary
Ovariectomized rabbits were injected with progesterone daily for 10 days with or without estradiol superimposed for the second half of the treatment period. After 5 days of treatment, one uterine horn was flushed with saline and after 10 days the opposite horn was flushed in a similar manner. The proportion of uterine fluid protein represented by “blastokinin” was similar on day 5 and on day 10 after treatment with either 3 mg/kg or 1 mg/kg of progesterone alone. Estradiol (5 μg/kg) at either dose of progesterone significantly reduced the proportion of “blastokinin.” Suppression of progesterone-induced synthesis of “blastokinin” by estradiol is consistent with the pattern of secretion of these steroids and the time-course of “blastokinin” during early pregnancy in the rabbit.
We thank Karl Ebert for his invaluable technical assistance.
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