Abstract
Summary
Inbred Chinese hamsters receiving 40 ppm diethylnitrosamine in their drinking water over a period of 17–26 weeks developed papillary growths of the esophagus and forestomach in all of the animals. In these lesions, squamous carcinoma was found in 23% of the stomach tumors and in 15% of esophageal growths. Hepatomas occurred in 13% of the animals and hepatic cirrhosis in 60%. Explantation of cirrhotic liver tissue in culture gave an epithelioid cell line with a pseudodiploid karyotype, 2n = 22. The highly inbred Chinese hamster appears to be a suitable model for studies involving carcinogenesis in the esophagus and stomach.
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