Suppression of Adjuvant Arthritis by Penicillamine in Pyridoxine Deficient Rats 1

Abstract

Summary

The administration of dl-penicillamine—a potent pyridoxine antagonist—to rats fed a diet low in vitamin B6 completely prevented the development of adjuvant arthritis. On the same regimen, d-penicillamine—a comparatively weak antivitamin—proved less effective. Neither the feeding of a pyridoxine deficient diet alone nor treatment with d-penicillamine on a complete ration modified the experimental disease. However, dl-penicillamine, even on a complete diet, partially reduced the intensity of the arthritic lesions without lowering their incidence.