Abstract
Summary
Infants 2-6 mo of age were given 3 doses of influenza hemagglutinin vaccine. One group received 250 CCA units of vaccine at intervals of 1 mo. A second group was given 250 CCA units with an interval of 2 mo between the first and second dose and an interval of 1 mo between the second and third dose. A slightly better antibody response was obtained with this schedule.
In a second experiment, infants 6-9 mo of age were given an initial series of either 300 CCA units of aqueous or aluminum phosphate adsorbed hemagglutinin vaccine. These infants exhibited a better antibody response than younger ones. When after 9-12 mo a third dose of the same vaccine was given, a secondary response was achieved. The response of infants who received adsorbed vaccine was slightly higher. The response of infants to polyvalent influenza hemagglutinin is similar to their response to other inactivated vaccines.
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