Abstract
Summary
A technique was developed to infuse rats for a period of several days. The alterations in electrolytes produced by infusion with an iso-osmotic solution of isethionate salts were studied. In comparison with iso-osmotic chloride salts infused controls, the amount of Cl- decreased and that of K+ increased in the urine while both Cl- and K+ levels decreased in the serum of rats infused with iso-osmotic isethionate salts. Concentration of Cl- in liver and kidney also decreased but no change occurred in brain chloride level. Potassium levels did not change in any of these tissues. In comparison with noninfused control, increases in serum glutamic–oxalacetic transaminase and alkaline phosphatase were noted in both isethionate and chloride receiving rats, while a decrease in lactic dehydrogenase was seen in isethionate receiving rats. Except for occasional lymphoid depletion in both groups, no other histopathological changes were seen. Similarly no hematological or urinary changes of pathological significance were noted.
The authors wish to express their gratitude to Dr. L. Simpson for carrying out histopathological examinations of the rat tissues and to Mr. D. James for his technical assistance.
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