Abstract
Summary
The influence of various experimental conditions, such as feeding schedule, composition of the diet, administration of a choleretic agent and vehicle used for its administration, on the development of indomethacin-induced intestinal ulcers in the rat has been studied.
Independently of diet composition, incidence of ulcer formation is reduced by starvation and favored by the presence of food. Regardless of feeding schedule, animals on a regular diet are significantly more susceptible to ulceration than those on the fat free diet.
The choleretic agent failed to enhance the ulcerogenic properties of indomethacin unless solubilized in sesame oil. Sesame oil alone significantly increased ulcer formation. These findings are discussed.
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