Abstract
Summary
Female rats show a significantly greater behavioral response than male rats to marijuana extract. This difference in response was partially abolished through castration of males or testosterone pretreatment of females. Since castration and testosterone pretreatment may affect drug metabolism, we also studied the effects of liver microsomal enzyme induction and inhibition on responses of rats to marijuana. While enzyme inhibition increased the responses of rats to marijuana, enzyme induction did not alter behavioral responses to marijuana.
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