Abstract
Summary
Human platelets separated by gel filtration on Sepharose 2B were tested for aggregation to ADP, collagen, and epinephrine. Normal aggregation was observed only with ADP. Associated with the lack of functional response to collagen and epinephrine was the release of abnormally small amounts of ADP and ATP. Assay of platelets after gel filtration indicated that significant amounts of ADP and ATP had been lost. By labeling platelets prior to filtration it was shown that the released adenine nucleotides came from both the metabolically active and the nonmetabolically active pool.
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