Local Vascular Effects of Alkalosis in the Dog Gracilis Muscle

Abstract

Summary

Experiments were completed in isolated, constant flow perfused, dog gracilis muscles to determine effects of local intra-arterial (IA) infusion of several alkalis on muscle vascular resistance. Stepwise increases in pH from approximately 7.44-7.60 with NaOH, Na₂CO₃, or NaHCO₃ did not alter resistance. Extreme increases in pH were associated with marked increases in vascular resistance, excepting NaHCO₃ which caused no change in resistance.

The technical assistance of D. B. McKeag and S. Underwood is gratefully acknowledged.