Abstract
Summary
Biliary phenol red (PR) excretion was measured in renal ligated male Wistar and homozygous Gunn strain rats. The amount of free PR excreted in the bile was similar in the two strains. Wistar rats excreted 32%-35% of PR as a glucuronide but only free PR was found in Gunn rat bile. Bile/plasma and bile/liver concentration ratios of free PR in Wistar rats are higher than those in Gunn rats. PR exhibits a mild choleretic effect in both strains.
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