Abstract
Summary
Host Versus Graft (HVG) syndrome is a fatal disease complex induced in parental strain mice by perinatal inoculations of F1 hybrid spleen cells, and manifested by platelet deficiency, intestinal hemorrhage, massively enlarged lymph nodes and spleen, thymic atrophy and renal disease. In this study, severe depression in splenic hemolytic plaque forming cell responses was observed in 25 day old RFM/(T6 × RFM) F1 mice. Histopathological surveys of the spleens revealed that depletion of lymphocytes in the thymic dependent areas of the white pulp accompanied an acute inflammatory reaction. Germinal centers and their accompanying lymphocytes, thought to be of bone marrow origin, were spared. Certain immunological and morphological similarities suggested that Graft Versus Host and Host Versus Graft diseases may have in common an induced deficiency of thymic derived (T) cells.
I thank Fr. G. Brede for plaque assays and Mr. J. Adams, for histological preparations. Supported in part by NIH grant AI-10, 136 and the Louis and Marguerite Privat Memorial Fund.
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