Abstract
Summary
Sotalol (MJ-1999) appears to act as a weak agonist in releasing catecholamines from isolated perfused bovine adrenals. Low concentrations of sotalol enhance and high concentrations inhibit acetylcholine-induced adrenal catecholamine release. Adrenal catecholamine release by high potassium media is decreased by sotalol only at high concentrations. Thus ganglionic actions of sotalol are seen at lower concentrations than are the local anesthetic actions. This study supports the suggestion that the effect of sotalol on blood sugar is due to enhanced adrenal catecholamine release and suggests that ganglionic blockade can be produced by sotalol in concentrations below those required for local anesthetic action.
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