Abstract
Summary
The effects of cholinergic drugs on serum prolactin concentration were determined in male and female rats. Acetylcholine bromide was injected once into the lateral ventricles of the brain, and pilocarpine nitrate and physostigmine sulfate were injected once ip. All drugs reduced serum prolactin values as compared to controls, although pilocarpine and physostigmine were more effective at lower than at higher dose levels. These results suggest an inhibitory role for the cholinergic system in the brain on prolactin release.
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