Impaired Elkind Recovery in Hematopoietic Colony-Forming Cells of Aged Mice 1,2

Abstract

Summary

Spleen colony-forming cells (CFU) in the bone marrow of old mice (25–27 months) are deficient in their ability to recover from fractionated sublethal doses of X-rays in vivo. This lack of repair is not evident from single-dose radiation survival data. Fractionation survival curves suggest that old CFU which survive the first dose of fractionated radiation may not be as radioresistant as comparable young (3 months) survivors.