Abstract
Summary
RNA synthesis directed by five arboviruses representing three virus groups was shown by radioautography to occur in the cytoplasm of infected BHK-21 cells and was not detected in the nucleus. EEE, a group A arbovirus (alphavirus), synthesized viral RNA in the peripheral cytoplasm, often in association with vacuoles. JBE, DEN-2, and POW (group B arboviruses or flaviviruses) synthesized viral RNA in the perinuclear area of the cytoplasm. LAX, a California group arbovirus (bunyavirus), did not manifest any particular pattern of localization within the cytoplasm.
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