Abstract
Summary
In choline deficiency, there is a decrease in activity of the phosphatidyl ethanolamine methyltransferase of liver microsomes. There is an impairment in the conversion of phosphatidyl ethanolamine to phosphatidyl choline via the Bremer-Green-berg pathway. The phosphatidyl choline synthesized via the Kennedy pathway shows that the choline phosphotransferase activity is unaltered in animals fed a diet made choline deficient by feeding 5% casein-5% fat and 1% guanidoacetic acid when compared to controls fed a 25% casein-5% fat diet. However in animals fed Purina laboratory chow which contains 2.4 mg choline/g diet, the choline phosphotransferase activity is 3.8 times greater than the values from rats fed the 25% casein-5% fat diet with no dietary choline.
Get full access to this article
View all access options for this article.