Abstract
Summary
The neutralization test by intracerebral inoculation of newborn mice can be satisfactorily carried out with at least 1 strain of Crimean hemorrhagic fever-Congo (CHF-C) virus; human sera showed no nonspecific antiviral activity and that of mouse sera was removed by acetone-ether extraction. An antigen usable in hemagglutination-inhibition (HI) tests has been developed with at least 2 strains of CHF-C virus. The cross-reactivity between CHF-C and Hazara viruses has been confirmed in the HI test.
The authors are indebted to Professor M. P. Chumakov, Moscow, for the serum from a patient recovered from CHF; to Dr. G. W., Kafuko, Entebbe, for samples of sera from 2 patients recovered from Congo virus clinical infections; and to Dr. S. Saidi, Teheran, for the serum from a sheep presumably naturally exposed to CHF-C virus or a related agent.
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