On the Hepatic Sulphurylating Activity in Male Pseudohermaphroditic Rats 1

Abstract

Summary

The sulphurylation of [1,2-³H]-deoxycorticosterone was studied in the 105,000g supernatant fluid obtained from liver homogenates of intact and castrated male pseudohermaphroditic, normal female, and normal male rats with and without treatment with steroid hormones. Male pseudohermaphroditic and normal female rats had similar sulphurylating activities which were higher than that of normal male rats. It was shown that the sulphurylating activity in male pseudohermaphroditic and normal female rats is normally regulated mainly by nongonadal factors and that the sulphurylating activity in normal male rats is suppressed by testicular androgens.