Abstract
Summary
Isolated cat papillary muscles immersed in Ringer's solution were subjected to metabolic acidosis (pH 6.9, Pco 2 = 40 mm Hg). Acidosis was produced at three temperatures of the bathing solution: 25, 30, and 38°. Acidosis at 25° was not followed by significant changes in contractility, whereas a negative inotropic effect was observed at 30 and 38°. The deletereous effect of acidosis was more marked at higher temperatures. It is possible that this effect might account in part for some of the controversies observed in the literature.
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