Abstract
Summary
Glucose-6-phosphatase was determined in fetal human and rat livers. It increased in activity with fetal age in both species. Culturing fetal livers for 24 hr in Eagle's essential medium had no effect on the enzyme. Addition of glucagon or dibutyryl cyclic AMP for the last 18 hr of culturing increased enzyme activity significantly in both man and rat. However, in fetal livers from rat fetuses weighing more than 4.6 g, this effect was not observed. Fructose-1,6-diphosphatase in human fetal liver also increased in activity between the 12th and 15th week of gestation, but neither glucagon nor dibutyryl cyclic AMP had any effect in cultures.
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