Abstract
Summary
Local production of nasopharyngeal γG and γM antibody to polio-virus was demonstrated in γA-deficient patients after intranasal immunization with inactivated Salk poliovacccine. Such local response appeared in the absence of a detectable antibody response in the serum. The level of nasopharyngeal γG antibody induced as a result of natural infection with rubella virus appeared to determine the success of intranasal reinfection with live attenuated rubella vaccine, regardless of the level of antibody in the serum. These data suggest that selective γA deficiency is effectively compensated by mucosal production of γG and γM viral antibodies.
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