Abstract
Summary
In rats, sc injections of nicotine tartrate during the critical period on the afternoon of vaginal proestrus delayed the spontaneous release of pituitary LH, FSH, and prolactin for approximately 2 hr. In ovariectomized rats, nicotine inhibited LH release but had no effect on plasma FSH or TSH concentration. Nicotine did not inhibit LH release in response to LHRH, and LHRH did not release FSH in proestrous or ovariectomized rats. The results support the view that two releasing hormones are involved in LH and FSH release.
The author thanks Dr. Leo Reichert, Jr., for his LER-1056-C2 LH for iodination, Dr. Gordon D. Niswender for his No. 15 antibody, and the National Institute of Arthritis and Metabolic Disease, Rat Pituitary Hormone Program, NIH, for the NIAMD materials.
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