Abstract
Summary
Rats maintained under controlled feeding schedules exhibit daily rhythms of the enzyme activities involved in folate metabolism. Tetrahydrofolate dehydrogenase and serine hydroxymethyl transferase show only small variations in their activity in the range of the 24-hr cycle. The 5,10-CH2-H4folate dehydrogenase shows a peak of activity at 6 PM (18:00), while the 5,10-CH2-H4folate synthetase activity reaches its lowest level between 3:00 PM (15:00) and 3:00 AM (3:00). The liver content of folate coenzymes does not change significantly during the whole day.
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