Abstract
Summary
The suggestion that a plasma humoral factor of extrarenal origin could cause a release of renin was investigated. For this, normal dogs were injected with plasma obtained from nephrectomized dogs in which hemorrhagic hypotension was produced 0.5 hr before the blood withdrawal. PRA was measured by radioimmunoassay before and after the injection of the plasma from the hypotensive, nephrectomized dogs. PRA did not increase after the injection of plasma. This work, therefore, fails to confirm the results previously reported by another group of investigators (4).
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