Body Fat and Fatty Acid Synthesis in Five Lines of Mice Selected for Growth Rate 1

Abstract

Summary

Two lines of mice (O₁₀ and C₁₀) were derived from an ICR strain. The O₁₀ mice weighed 52 g and contained 15.5% fat while the C₁₀ mice weighed 36 g and contained 8.3% fat at 14 weeks of age. At this time, the O₁₀ mice exhibited hyperglycemia and an increased rate of hepatic fatty acid synthesis when compared with the C₁₀ mice. Although three other lines of mice (H₆, C₂, and L₆) derived by reciprocally crossing CAF₁ and AKD2F₁ mice exhibited marked differences in body weight at 14 weeks of age (H₆ = 37 g; C₂ = 29 g; and L = 22 g), the percentage of body fat, blood glucose values, and in vitro rates of fatty acid synthesis in liver and adipose tissue were similar in these mice.