Abstract
Summary
Exposure of hamster pancreatic islets to a low concentration of hyaluronidase during isolation by means of collagenase causes reversible inhibition of the insulino-tropic action of tolbutamide without apparently affecting glucose-stimulated insulin secretion. This inhibition is not attributable to the collagenase. These findings suggest that the inhibitory action of hyaluronidase on the insulinotropic action of tolbutamide may be exerted through a mechanism involving a cellular receptor for tolbutamide, possibly associated with the beta cell plasma membrane, different from that for glucose.
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