Inhibition of Mammary Dysplasia in Estrogen-Treated C3H/HeJ Female Mice by Treatment with 2-Bromo-α-ergocryptine

Abstract

Summary

Five-month-old ovariectomized and hysterectomized C3H/HeJ mice were chronically treated for 1 year with 17β-estradiol. Half of the mice concurrently received daily injections of 2-bromo-α-ergo-cryptine (CB-154), an efficacious inhibitor of prolactin secretion. CB-154 treatment significantly (a) inhibited hyperplastic alveolar nodule (HAN) development, (b) reduced mammary tumor incidence, and (c) suppressed mammary gland development. These results suggest that estrogen-induced mammary dysplasia can be significantly reduced in C3H/HeJ female mice by drug-induced inhibition of pituitary prolactin secretion.

Thanks are given to Carol Gribler for her assistance in this study.