Abstract
Summary
Measurements have been made of the binding of HCG to intact follicles isolated from rabbit ovaries. Competition studies suggest that HCG and LH are bound to the same or overlapping binding sites, while FSH does not appear to compete with HCG for binding. Follicles isolated from unmated, preovulatory, or postovulatory rabbits bind HCG equally well. It is therefore concluded that the cessation in steroidogenesis which occurs just prior to ovulation in the rabbit cannot be attributed to a failure of the follicle to bind the stimulating gonadotropins.
The authors express their gratitude to Professor V. B. Mahesh for his valuable suggestions and review of the manuscript. The excellent technical assistance of Mr. John Waterson III is also acknowledged.
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