Abstract
Summary
It has been reported that antibody-forming capacity in athymic (nude) mice can be restored only by transplantation of thymus cells from histocompatible donors. In experiments reported here, nude mice received, 4 weeks prior to the injection of sheep erythrocytes, solid thymus grafts from neonatal or 3-week-old allogeneic donors. Restoration of antibody-forming capacity and persistence of transplants at the graft site were observed in animals receiving neonatal but not in animals receiving 3-week-old thymus tissue.
We gratefully acknowledge the skillful technical assistance of Miss Lesley Ann Radov.
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