Abstract
Summary
Prenatal administration of anti-LH:FSH advances puberty and increases the diestrus phase of pubertal estrous cycles and the estrus phase of adult cycles. A prenatal injection of cyanoketone, by contrast, delays puberty and prolongs both phases of pubertal and adult estrous cycles. An enhancement of the effects of either agent is obtained with additional neonatal treatment. Each treatment affects subsequent pregnancy by reducing placental and/or fetal weights. Thus, programming of adult reproductive function in the female rat can be disturbed during fetal life.
The technical assistance of Theodore Schneider is gratefully acknowledged. Bovine luteinizing hormone and purified rat pituitary hormones were obtained from the Rat Hormone Distribution Program through the Hormone Distribution Officer, NIAMDD, NIH.
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