Abstract
Summary
Male Sprague–Dawley rats were made diabetic with streptozotocin (65 mg/kg, iv). Severe polyuria and glycosuria were accompanied by a marked increase in the 24-hr urinary excretion of bound hexosamine. There was a slight but significant increase of liver hexosamine in the treated rats compared with their age matched controls, although the activity of hepatic glucosamine synthetase was unchanged. The results support the hypothesis that glucosamine synthesis and incorporation into macromolecules are enhanced in this type of experimental diabetes.
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