Abstract
Summary
A fraction has been obtained from highly purified rat liver mitochondria which contains lysosomes and peroxisomes exhibiting a bimodal distribution on a linear sucrose density gradient. This fraction, which represents less than 1% of the total protein of the original mitochondria, was obtained after removal of the bulk of the heavier particles by lower speed centrifugations. The sucrose concentrations at which the two peaks (for lysosomes) and major peak and shoulder (for peroxisomes) equilibrate are highly reproducible as shown by statistical analysis.
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