Abstract
Summary
Pretreatment of male rats with spironolactone resulted in protection against CCl4 hepatotoxicity. This protection was evidenced by decreased reduction of liver glucose-6-phosphatase activity, smaller rises in SGOT and SGPT, and less severe hepatic damage as observed by histological examination. Spironolactone pretreatment and spironolactone in vitro both decreased lipid peroxidation due to CCl4 as measured by malonaldehyde formation.
The authors acknowledge the technical assistance of Mrs. Barbara Schultz, Mrs. Arlene Johnson, and Mrs. Nadylis Wood. The spironolactone was a gift of Searle and Company. This work was supported by NIEHS Grant 00596.
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