Abstract
Summary
The immunogenicity and anti-genicity of sheep, horse, goat and chicken erythrocytes (RBC) were studied following their exposure to Vibrio cholera neuraminidase. BALB/c mice immunized with neura-minidase treated sheep or horse RBC had approximately a 15-20-fold decrease in the number of splenic plaque forming cells and corresponding reductions in serum hemagglutinin and hemolysin titers. When neuraminidase treated sheep erythrocytes were used as target cells in the hemolytic plaque assay a fourfold reduction in PFC was noted. These data suggest that sialic acid is an important constituent of glycoprotein antigens of sheep and horse erythrocyte membranes. In contrast to these findings, there was no alteration in either immunogenicity or antigenicity of chicken erythrocytes following their treatment with neuraminidase.
Get full access to this article
View all access options for this article.