Effect of Prostaglandin F 2α (PGF 2α ) on Venous Contractility and 45 Ca Uptake 1

Abstract

Summary

PGF_2α enhanced the contractile responses of superfused helical strips of canine cutaneous venous smooth muscle to norepinephrine and the ionic stimulant, barium chloride, in the absence of any significant effect of PGF_2α on venous tone. PGF_2α also enhanced norepinephrine-induced ⁴⁵Ca uptake as well as the rate of ⁴⁵Ca exchange. It was concluded that PGF_2α acts to enhance smooth muscle membrane permeability to calcium ion. In addition, it appears that PGF_2α may act within the smooth muscle cell to enhance the rate of transcellular calcium exchange.