Abstract
Summary and Conclusion
Plasma obtained from dogs during the posthemorrhage period increased the absorption of sodium in the everted rat segment over control values.
The plasma obtained after dogs were infused for 60 min with angiotensin (1 μg/min) also resulted in a significant increase in sodium absorption in the everted gut preparation over the control values.
Angiotensin added directly to the serosal solution in the everted rat gut did not increase sodium absorption.
Vasopressin at a concentration equivalent to that found following a 20% hemorrhage had no effect on sodium absorption.
In conclusion, the experimental evidence supports the hypothesis that following contraction of the blood volume there is a change in the composition of the plasma that does significantly affect the absorption of sodium in an everted rat segment. This mechanism present in the intestine, then, should complement the role of the kidney in the homeostatic regulation of total body sodium.
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