Abstract
Summary
The plasma cholesterol levels of 6-month-old 500-g male retired breeder rats were significantly higher than the plasma cholesterol levels of 71-day-old 200-g adult male rats of the same strain. Oxandrolone administration daily for 21 days reduced the plasma cholesterol of the retired breeder rats 41% to a level below that of the young adult males. There was no difference in weight between the oxandrolone-treated retired breeder rats and their controls. The hypocholesterolemic properties of oxandrolone and the virtues of retired breeder rats as an experimental model are discussed.
This research was supported in part by the Veterans Administration Hospital and G. D. Searle and Company.
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