Abstract
Summary
Investigation was made of what role histamine plays in the gastric secretion induced by a new avian pancreatic polypeptide (APP). Use of an anticholinergic agent (glycopyrrolate bromide) was made to block the gastric effects of histamine in adult chickens. However, this agent was without effect on the stimulatory action of APP as measured by secretory volume, H+, pepsin, and protein levels. The pancreatic polypeptide action, therefore, is not mediated by histamine release in chickens, and, in fact, APP may be avian gastrin.
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