Abstract
Summary
The major detectable pyrrole metabolite of the pyrrolizidine alkaloid, monocrotaline, present in the liver, blood, and urine of rats, has been identified as dehydroretronecine. The subcutaneous injection of this metabolite into rats produces ulceration and hemorrhage of the stomach wall. Inhibition of hepatic parenchymal cell mitosis in regenerating liver was recorded within 52 hr following its administration and persisted for at least 6 weeks.
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