Abstract
Summary
Candida extract caused significant tritiated-thymidine uptake (> 5,000 cpm, S/C > 4) in lymphocyte cultures from all normal adults tested. In contrast, in 22% of hospitalized patients, the antigen produced transformation less than any normal subject, and S/C < 4. The difference in candidainduced transformation between normal and hospitalized subjects was statistically significant, while no significant difference in conventional PHA stimulation could be demonstrated.
The author thanks Mr. B. B. Cartwright and Miss S. E. Hieny for technical assistance, and Dr. R. Vander Zwaag for performing statistical analyses.
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