Abstract
Summary
A very low cyclic GMP concentration (5 × 10–11 M) causes the actively “cycling” lymphoblasts in isolated rat thymic lymphocyte populations to start synthesizing DNA by a calcium-independent process. These stimulated cells are able to progress subsequently through the DNA-synthetic phase and enter mitosis. The possible significance of the cyclic GMP-induced stimulatory action in the regulation of lymphoblast proliferation is discussed. An attempt is also made to interrelate the similar actions of cyclic GMP and cyclic AMP.
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