Abstract
Summary
The CV1 strain of vaccinia virus replicates poorly in human embryo kidney cells whereas most vaccinia strains such as the U.S. Reference smallpox vaccine replicate well in this host system. Absorption by the cell and production of viral antigen proceed at the same rate for both strains. Electron micrographs reveal that the CV1 strain produces immature forms of particles which do not possess a dense nucleoid of DNA material. Very few normal mature particles are formed and bizarre particles are found in the cytoplasm. CV1 DNA synthesis seems unable to proceed in the normal fashion in these cells.
The interest and counsel of Dr. L. F. Barker is deeply appreciated by the author. I am also grateful for the technical assistance of Mrs. Glennelle C. Washington.
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