Abstract
Summary
Sulfapyridine potentiates the analgesic effect of morphine. It also produces analgesia when administered to morphinepretreated mice long after the analgesic effect of morphine has worn off. Morphine possibly binds to blood and/or tissue components, most likely in the brain, forming pharmacologically inactive complexes, and sulfapyridine prevents and/or reverses the binding, thus freeing active morphine.
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