Abstract
Summary
A significant increase was induced by lathyrism in the small fraction of collagen-like material solubilized from rat glomeruli. An increased affinity and staining by PTA of fibrils within the GBM of lathyritic rats was found by electron microscopy, and also probably reflects an alteration in the collagen-like moiety of the GBM by APN, a material known to affect the cross-linking of collagens. No change in total proteinuria was found in lathyritic rats, nor other major changes in renal structure by conventional microscopy, electron microscopy, or specialized stains of the sialoprotein layer of the glomerulus. Further study of physicochemical alterations induced in the GBM combined with methods to evaluate glomerular permeability, may reveal the location and nature of the filtration barrier.
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