Abstract
Summary
In hyperphenylalaninemia induced by daily injections of phenylalanine to growing rats, the entry of α-methyl-D-glucose or glucose into the brain is not hindered. Thus, defective utilization of glucose due to high levels of phenylalanine and its metabolites appears to be the reason for its reduced incorporation into lipids and proteins. On the other hand, decreased incorporation into proteins of amino acids such as glutamic acid and leucine appears to be due to the poor uptake by the brain of these amino acids.
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