Abstract
Summary
The kinetics of acid inactivation of human rhinovirus type 14 are affected by pH and temperature of incubation.
At pH 3.0, inactivation was complete within 10 sec with total loss of infectivity. At pH 5.0, inactivation reached a maximum by 20 min and yielded a persistent fraction of infectious virus. This surviving fraction was eliminated when the pH was lowered to 3.0. At 0° no loss of infectivity was observed after 5 min of incubation at pH 5.0, while at room temperature 99% of the infectivity was lost. The characteristics of rhinovirus inactivation at low pH appears to be different from all other picornaviruses.
This investigation was supported by Research Contract 69-2062 from the Infectious Disease Branch of the National Institutes of Health, and by Public Health Service General Research Support Grant RR-05504 from the Children's Hospital Research Foundation, Columbus, Ohio 43205. The authors would like to thank Miss Helen Rehn for typing the manuscript.
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